Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9848

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.30, p 0.430). This receipt's hash covers every field on it, plus the hash of receipt 9847, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9848
    25 Oct 2026, 15:13 UTC

    IRF5

    dopamine neurons, braak

    predictionIRF5 in dopamine neurons tracks Braak Lewy-body stage

    registered4b239cdb299dd530

    discovery-0.30 p=0.430 n=9

    replication-0.37 p=0.334 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.30, p 0.430)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    5b838da631541a921feb7788…
    follows 8f6036935a22…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9848: IRF5 in dopamine neurons, braak

power
full sample -0.36 (p 0.142, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.36 (p 0.142, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.47 (p 0.051, n 18). could be the mix.
skeptic
leave-one-out range -0.50 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.142, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IRF5 in dopamine neurons.

case closed: nothing better to follow up.