parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (51 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 1,122	0.82
pathways Reactome	3 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 9839

receipt 9848: IRF5 in dopamine neurons, braak

power: full sample -0.36 (p 0.142, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.36 (p 0.142, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.47 (p 0.051, n 18). could be the mix.
skeptic: leave-one-out range -0.50 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.142, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IRF5 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9847: IRF5 in microglia, braak

power: full sample -0.31 (p 0.207, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.31 (p 0.211, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.36 (p 0.137, n 18). could be the mix.
skeptic: leave-one-out range -0.50 to -0.21, sign flips 0; without severely affected donors -0.31 (p 0.207, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IRF5 in microglia.

case closed: nothing better to follow up.

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