Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5066

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.05, p 0.893). This receipt's hash covers every field on it, plus the hash of receipt 5065, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5066
    21 Oct 2026, 07:14 UTC

    OTX1

    dopamine neurons, braak

    predictionOTX1 in dopamine neurons tracks Braak Lewy-body stage

    registeredcbc7172c8ba87c2b

    discovery-0.05 p=0.893 n=9

    replication-0.43 p=0.247 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.05, p 0.893)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f0b28945b6ba363ce293e689…
    follows 397b82519d1a…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5066: OTX1 in dopamine neurons, braak

power
full sample -0.27 (p 0.273, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.24 (p 0.332, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.20 (p 0.424, n 18). could be the mix.
skeptic
leave-one-out range -0.46 to -0.20, sign flips 0; without severely affected donors -0.27 (p 0.273, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for OTX1 in dopamine neurons.

case closed: nothing better to follow up.