parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in lacrimal acinar cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 266	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 5058

receipt 5066: OTX1 in dopamine neurons, braak

power: full sample -0.27 (p 0.273, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.24 (p 0.332, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.20 (p 0.424, n 18). could be the mix.
skeptic: leave-one-out range -0.46 to -0.20, sign flips 0; without severely affected donors -0.27 (p 0.273, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for OTX1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5065: OTX1 in astrocytes, braak

power: full sample -0.15 (p 0.561, n 18), 95% CI -0.57 to +0.34. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.15 (p 0.561, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.12 (p 0.646, n 18). could be the mix.
skeptic: leave-one-out range -0.26 to -0.02, sign flips 0; without severely affected donors -0.15 (p 0.561, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for OTX1 in astrocytes.

case closed: nothing better to follow up.

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