Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5065

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.30, p 0.426). This receipt's hash covers every field on it, plus the hash of receipt 5064, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5065
    21 Oct 2026, 07:14 UTC

    OTX1

    astrocytes, braak

    predictionOTX1 in astrocytes tracks Braak Lewy-body stage

    registerede39c577af11b80ac

    discovery-0.30 p=0.426 n=9

    replication-0.35 p=0.361 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.30, p 0.426)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    397b82519d1ac29ca71b35ff…
    follows ab859fd1cfc1…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5065: OTX1 in astrocytes, braak

power
full sample -0.15 (p 0.561, n 18), 95% CI -0.57 to +0.34. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.15 (p 0.561, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.12 (p 0.646, n 18). could be the mix.
skeptic
leave-one-out range -0.26 to -0.02, sign flips 0; without severely affected donors -0.15 (p 0.561, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for OTX1 in astrocytes.

case closed: nothing better to follow up.