Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0503

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.10, p 0.802). This receipt's hash covers every field on it, plus the hash of receipt 502, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0503
    17 Oct 2026, 02:26 UTC

    EPM2A

    dopamine neurons, braak

    predictionEPM2A in dopamine neurons tracks Braak Lewy-body stage

    registeredd8d2a3ab1f98b07e

    discovery-0.10 p=0.802 n=9

    replication+0.54 p=0.136 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.10, p 0.802)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    764a766239023c1a2ac7c3ef…
    follows 21f32df67577…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0503: EPM2A in dopamine neurons, braak

power
full sample +0.13 (p 0.609, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.14 (p 0.579, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.15 (p 0.555, n 18). could be the mix.
skeptic
leave-one-out range +0.03 to +0.29, sign flips 0; without severely affected donors +0.13 (p 0.609, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for EPM2A in dopamine neurons.

case closed: nothing better to follow up.