Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2983

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.11, p 0.787). This receipt's hash covers every field on it, plus the hash of receipt 2982, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2983
    19 Oct 2026, 09:46 UTC

    APAF1

    dopamine neurons, braak

    predictionAPAF1 in dopamine neurons tracks Braak Lewy-body stage

    registered8f18c2f650f69813

    discovery-0.11 p=0.787 n=9

    replication+0.38 p=0.316 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.11, p 0.787)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    71728c27c5920ec3c0258373…
    follows 1be855a719ea…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2983: APAF1 in dopamine neurons, braak

power
full sample +0.04 (p 0.888, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.976, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.983, n 18). could be the mix.
skeptic
leave-one-out range -0.04 to +0.15, sign flips 6; without severely affected donors +0.04 (p 0.888, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for APAF1 in dopamine neurons.

case closed: nothing better to follow up.