parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.09 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophil progenitors	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	20 Parkinson's papers of 2,193	0.60
pathways Reactome	8 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 2975

receipt 2983: APAF1 in dopamine neurons, braak

power: full sample +0.04 (p 0.888, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.01 (p 0.976, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.983, n 18). could be the mix.
skeptic: leave-one-out range -0.04 to +0.15, sign flips 6; without severely affected donors +0.04 (p 0.888, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for APAF1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2982: APAF1 in microglia, braak

power: full sample -0.11 (p 0.677, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.07 (p 0.794, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.00 (p 0.997, n 18). could be the mix.
skeptic: leave-one-out range -0.19 to +0.03, sign flips 3; without severely affected donors -0.11 (p 0.677, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for APAF1 in microglia.

case closed: nothing better to follow up.

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