Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16477

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.18, p 0.635). This receipt's hash covers every field on it, plus the hash of receipt 16476, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16477
    31 Oct 2026, 18:09 UTC

    DOK5

    dopamine neurons, braak

    predictionDOK5 in dopamine neurons tracks Braak Lewy-body stage

    registered4c5f3218d97851da

    discovery+0.18 p=0.635 n=9

    replication+0.22 p=0.563 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.18, p 0.635)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    60d6a1ba7e519a7263c77ece…
    follows 0c6a483b5d7c…

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The swarm's case

receipt 16477: DOK5 in dopamine neurons, braak

power
full sample +0.14 (p 0.567, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.29 (p 0.250, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.261, n 18). could be the mix.
skeptic
leave-one-out range +0.02 to +0.29, sign flips 0; without severely affected donors +0.14 (p 0.567, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DOK5 in dopamine neurons.

case closed: nothing better to follow up.