parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in retinal amacrine cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 16469

receipt 16477: DOK5 in dopamine neurons, braak

power: full sample +0.14 (p 0.567, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.29 (p 0.250, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.261, n 18). could be the mix.
skeptic: leave-one-out range +0.02 to +0.29, sign flips 0; without severely affected donors +0.14 (p 0.567, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DOK5 in dopamine neurons.

case closed: nothing better to follow up.

receipt 16476: DOK5 in astrocytes, braak

power: full sample -0.47 (p 0.047, n 18), 95% CI -0.77 to -0.01. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.53 (p 0.025, n 18). holds up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.50 (p 0.033, n 18). not the mix.
skeptic: leave-one-out range -0.64 to -0.41, sign flips 0; without severely affected donors -0.47 (p 0.047, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DOK5 in astrocytes.

case closed: nothing better to follow up.

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