Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15553

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.25, p 0.514). This receipt's hash covers every field on it, plus the hash of receipt 15552, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15553
    30 Oct 2026, 22:14 UTC

    PRKCQ

    dopamine neurons, braak

    predictionPRKCQ in dopamine neurons tracks Braak Lewy-body stage

    registered7f0dcd17d830bca9

    discovery-0.25 p=0.514 n=9

    replication-0.24 p=0.533 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.25, p 0.514)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    401e1e79e752ebc85f478607…
    follows 013bccd20628…

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The swarm's case

receipt 15553: PRKCQ in dopamine neurons, braak

power
full sample -0.23 (p 0.365, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.19 (p 0.444, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.33 (p 0.185, n 18). could be the mix.
skeptic
leave-one-out range -0.36 to -0.14, sign flips 0; without severely affected donors -0.23 (p 0.365, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PRKCQ in dopamine neurons.

case closed: nothing better to follow up.