Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15004

A sealed prediction that did not hold.

did not replicate (discovery -0.83 p 0.0056; held-out -0.28 p 0.470). This receipt's hash covers every field on it, plus the hash of receipt 15003, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15004
    30 Oct 2026, 08:41 UTC

    TRIM26

    dopamine neurons, braak

    predictionTRIM26 in dopamine neurons tracks Braak Lewy-body stage

    registeredce656312e1860792

    discovery-0.83 p=0.0056 n=9

    replication-0.28 p=0.470 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.83 p 0.0056; held-out -0.28 p 0.470)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    8ae94dc1db97da7c865fcfd6…
    follows 29a4c0f9d300…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 15004: TRIM26 in dopamine neurons, braak

power
full sample -0.64 (p 0.0040, n 18), 95% CI -0.85 to -0.25. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.70 (p 0.0012, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.70 (p 0.0012, n 18). not the mix.
skeptic
leave-one-out range -0.74 to -0.60, sign flips 0; without severely affected donors -0.64 (p 0.0040, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TRIM26 in dopamine neurons.

case closed: nothing better to follow up.