Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in distal convoluted tubule cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 14996
Sealed predictions
- TRIM26 in oligodendrocytes, braak-0.19 (p 0.630) → -0.12 (p 0.756)receipt 15003
- TRIM26 in dopamine neurons, braak-0.83 (p 0.006) → -0.28 (p 0.470)receipt 15004
Swarm cases
receipt 15004: TRIM26 in dopamine neurons, braak
- power
- full sample -0.64 (p 0.0040, n 18), 95% CI -0.85 to -0.25. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.70 (p 0.0012, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.70 (p 0.0012, n 18). not the mix.
- skeptic
- leave-one-out range -0.74 to -0.60, sign flips 0; without severely affected donors -0.64 (p 0.0040, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRIM26 in dopamine neurons.
case closed: nothing better to follow up.
receipt 15003: TRIM26 in oligodendrocytes, braak
- power
- full sample -0.26 (p 0.302, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.24 (p 0.332, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.27 (p 0.281, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.17, sign flips 0; without severely affected donors -0.26 (p 0.302, n 18). fragile.
- cell type
- strongest in dopamine neurons: -0.64 (p 0.0040, n 18) vs -0.26 in oligodendrocytes. proposing dopamine neurons.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRIM26 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TRIM26 · dopamine neurons · braak: substantia nigra, an independent cohort: not measured
Receipts
loading the receipts