Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14470

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.59, p 0.098). This receipt's hash covers every field on it, plus the hash of receipt 14469, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14470
    29 Oct 2026, 21:15 UTC

    FAM149A

    dopamine neurons, braak

    predictionFAM149A in dopamine neurons tracks Braak Lewy-body stage

    registered89e44e778d50ae6b

    discovery-0.59 p=0.098 n=9

    replication-0.23 p=0.555 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.59, p 0.098)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a0a8ca53219a8af2cb0bf20b…
    follows 9a46abf5306c…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 14470: FAM149A in dopamine neurons, braak

power
full sample -0.33 (p 0.188, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.50 (p 0.034, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.064, n 18). could be the mix.
skeptic
leave-one-out range -0.45 to -0.23, sign flips 0; without severely affected donors -0.33 (p 0.188, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FAM149A in dopamine neurons.

case closed: nothing better to follow up.