parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (620 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 14462

FAM149A in microglia, braak-0.49 (p 0.179) → -0.28 (p 0.466)receipt 14469
FAM149A in dopamine neurons, braak-0.59 (p 0.098) → -0.23 (p 0.555)receipt 14470

receipt 14470: FAM149A in dopamine neurons, braak

power: full sample -0.33 (p 0.188, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.50 (p 0.034, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.064, n 18). could be the mix.
skeptic: leave-one-out range -0.45 to -0.23, sign flips 0; without severely affected donors -0.33 (p 0.188, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FAM149A in dopamine neurons.

case closed: nothing better to follow up.

receipt 14469: FAM149A in microglia, braak

power: full sample -0.22 (p 0.374, n 18), 95% CI -0.62 to +0.27. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.23 (p 0.351, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.27 (p 0.273, n 18). could be the mix.
skeptic: leave-one-out range -0.37 to -0.11, sign flips 0; without severely affected donors -0.22 (p 0.374, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FAM149A in microglia.

case closed: nothing better to follow up.

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