Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14236

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.23, p 0.554). This receipt's hash covers every field on it, plus the hash of receipt 14235, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14236
    29 Oct 2026, 15:59 UTC

    FLRT1

    oligodendrocytes, braak

    predictionFLRT1 in oligodendrocytes tracks Braak Lewy-body stage

    registered2459b0866af902e7

    discovery-0.23 p=0.554 n=9

    replication-0.16 p=0.685 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.23, p 0.554)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    fd639d934ce2b6520561bb91…
    follows a086c1afa338…

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The swarm's case

receipt 14236: FLRT1 in oligodendrocytes, braak

power
full sample -0.16 (p 0.538, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.03 (p 0.908, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.03 (p 0.908, n 18). could be the mix.
skeptic
leave-one-out range -0.31 to -0.06, sign flips 0; without severely affected donors -0.16 (p 0.538, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FLRT1 in oligodendrocytes.

case closed: nothing better to follow up.