Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in myonuclei | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 14228
Sealed predictions
- FLRT1 in oligodendrocytes, braak-0.23 (p 0.554) → -0.16 (p 0.685)receipt 14236
- FLRT1 in dopamine neurons, braak-0.13 (p 0.739) → -0.46 (p 0.212)receipt 14237
Swarm cases
receipt 14237: FLRT1 in dopamine neurons, braak
- power
- full sample -0.42 (p 0.086, n 18), 95% CI -0.74 to +0.06. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.49 (p 0.039, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.070, n 18). could be the mix.
- skeptic
- leave-one-out range -0.54 to -0.34, sign flips 0; without severely affected donors -0.42 (p 0.086, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FLRT1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 14236: FLRT1 in oligodendrocytes, braak
- power
- full sample -0.16 (p 0.538, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.03 (p 0.908, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.03 (p 0.908, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.06, sign flips 0; without severely affected donors -0.16 (p 0.538, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FLRT1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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