Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13273

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.11, p 0.787). This receipt's hash covers every field on it, plus the hash of receipt 13272, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13273
    28 Oct 2026, 18:17 UTC

    ENPP6

    dopamine neurons, braak

    predictionENPP6 in dopamine neurons tracks Braak Lewy-body stage

    registered937c9181e5f292c5

    discovery-0.11 p=0.787 n=9

    replication-0.04 p=0.928 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.11, p 0.787)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    69fc8271d7ab80c699e965a2…
    follows b05ef32e495f…

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The swarm's case

receipt 13273: ENPP6 in dopamine neurons, braak

power
full sample -0.09 (p 0.709, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.08 (p 0.761, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.11 (p 0.664, n 18). could be the mix.
skeptic
leave-one-out range -0.23 to +0.01, sign flips 1; without severely affected donors -0.09 (p 0.709, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ENPP6 in dopamine neurons.

case closed: nothing better to follow up.