Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11615

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.09, p 0.815). This receipt's hash covers every field on it, plus the hash of receipt 11614, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11615
    27 Oct 2026, 05:48 UTC

    ERBB3

    dopamine neurons, braak

    predictionERBB3 in dopamine neurons tracks Braak Lewy-body stage

    registereda2b78588b2817ef2

    discovery-0.09 p=0.815 n=9

    replication-0.56 p=0.117 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.09, p 0.815)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b92b1453c31b907d7a0860db…
    follows 03293190c382…

Covered by the on-chain checkpoint of receipt 11630 (2026-10-27 06:08 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11615: ERBB3 in dopamine neurons, braak

power
full sample -0.22 (p 0.389, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.26 (p 0.298, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.201, n 18). could be the mix.
skeptic
leave-one-out range -0.35 to -0.10, sign flips 0; without severely affected donors -0.22 (p 0.389, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ERBB3 in dopamine neurons.

case closed: nothing better to follow up.