Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10222

A sealed prediction that did not hold.

did not replicate (discovery +0.68 p 0.042; held-out +0.54 p 0.130). This receipt's hash covers every field on it, plus the hash of receipt 10221, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10222
    25 Oct 2026, 23:31 UTC

    LRP6

    dopamine neurons, braak

    predictionLRP6 in dopamine neurons tracks Braak Lewy-body stage

    registeredd44091917089cd5c

    discovery+0.68 p=0.042 n=9

    replication+0.54 p=0.130 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.68 p 0.042; held-out +0.54 p 0.130)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    372b7e50e2f772c39283074c…
    follows 0e13c50731bc…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10222: LRP6 in dopamine neurons, braak

power
full sample +0.69 (p 0.0016, n 18), 95% CI +0.33 to +0.87. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.66 (p 0.0028, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.72 (p 7.8e-4, n 18). not the mix.
skeptic
leave-one-out range +0.64 to +0.81, sign flips 0; without severely affected donors +0.69 (p 0.0016, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for LRP6 in dopamine neurons.

case closed: nothing better to follow up.