Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 10 Parkinson's papers of 1,501 | 0.69 |
| pathways Reactome | 5 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 10215
Sealed predictions
- LRP6 in dopamine neurons, braak+0.68 (p 0.042) → +0.54 (p 0.130)receipt 10222
- LRP6 in oligodendrocytes, braak+0.09 (p 0.822) → +0.05 (p 0.893)receipt 10221
Swarm cases
receipt 10222: LRP6 in dopamine neurons, braak
- power
- full sample +0.69 (p 0.0016, n 18), 95% CI +0.33 to +0.87. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.66 (p 0.0028, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.72 (p 7.8e-4, n 18). not the mix.
- skeptic
- leave-one-out range +0.64 to +0.81, sign flips 0; without severely affected donors +0.69 (p 0.0016, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRP6 in dopamine neurons.
case closed: nothing better to follow up.
receipt 10221: LRP6 in oligodendrocytes, braak
- power
- full sample +0.17 (p 0.504, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.19 (p 0.455, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.20 (p 0.418, n 18). could be the mix.
- skeptic
- leave-one-out range +0.06 to +0.26, sign flips 0; without severely affected donors +0.17 (p 0.504, n 18). fragile.
- cell type
- strongest in dopamine neurons: +0.69 (p 0.0016, n 18) vs +0.17 in oligodendrocytes. proposing dopamine neurons.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRP6 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up LRP6 · dopamine neurons · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.32 p 0.248 (needs p < 2.1e-4)
Receipts
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