Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10187

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.55, p 0.122). This receipt's hash covers every field on it, plus the hash of receipt 10186, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10187
    25 Oct 2026, 22:44 UTC

    ACAP3

    dopamine neurons, braak

    predictionACAP3 in dopamine neurons tracks Braak Lewy-body stage

    registeredaad3de1fceeb4e88

    discovery-0.55 p=0.122 n=9

    replication-0.60 p=0.090 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.55, p 0.122)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    4b584ca3ad6d50e71cc8de57…
    follows 688d1110cefb…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10187: ACAP3 in dopamine neurons, braak

power
full sample -0.64 (p 0.0040, n 18), 95% CI -0.85 to -0.25. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.63 (p 0.0055, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.62 (p 0.0064, n 18). not the mix.
skeptic
leave-one-out range -0.69 to -0.60, sign flips 0; without severely affected donors -0.64 (p 0.0040, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ACAP3 in dopamine neurons.

case closed: nothing better to follow up.