parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in astrocytes (426 nCPM)	1.00
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 49	0.91
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 13477

TTYH1 in astrocytes, braak+0.15 (p 0.705) → -0.07 (p 0.855)receipt 13484
TTYH1 in dopamine neurons, braak-0.57 (p 0.111) → -0.32 (p 0.402)receipt 13485

receipt 13485: TTYH1 in dopamine neurons, braak

power: full sample -0.45 (p 0.060, n 18), 95% CI -0.76 to +0.02. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.48 (p 0.044, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.47 (p 0.049, n 18). not the mix.
skeptic: leave-one-out range -0.55 to -0.39, sign flips 0; without severely affected donors -0.45 (p 0.060, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TTYH1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 13484: TTYH1 in astrocytes, braak

power: full sample +0.08 (p 0.754, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.06 (p 0.827, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.16 (p 0.515, n 18). could be the mix.
skeptic: leave-one-out range -0.03 to +0.21, sign flips 3; without severely affected donors +0.08 (p 0.754, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TTYH1 in astrocytes.

case closed: nothing better to follow up.

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