Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in neutrophils | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 230 | 0.85 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 9957
Sealed predictions
- TRIM22 in dopamine neurons, braak+0.36 (p 0.341) → +0.58 (p 0.103)receipt 9965
- TRIM22 in microglia, braak+0.17 (p 0.668) → -0.06 (p 0.886)receipt 9964
Swarm cases
receipt 9965: TRIM22 in dopamine neurons, braak
- power
- full sample +0.47 (p 0.050, n 18), 95% CI +0.00 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.46 (p 0.057, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.43 (p 0.077, n 18). could be the mix.
- skeptic
- leave-one-out range +0.38 to +0.60, sign flips 0; without severely affected donors +0.47 (p 0.050, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRIM22 in dopamine neurons.
case closed: nothing better to follow up.
receipt 9964: TRIM22 in microglia, braak
- power
- full sample +0.19 (p 0.439, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.19 (p 0.455, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.18 (p 0.471, n 18). could be the mix.
- skeptic
- leave-one-out range +0.13 to +0.38, sign flips 0; without severely affected donors +0.19 (p 0.439, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRIM22 in microglia.
case closed: nothing better to follow up.
Receipts
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