parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	group enriched, including microglia; strongest in hofbauer cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 15998

TMIGD3 in dopamine neurons, braak+0.15 (p 0.697) → -0.08 (p 0.842)receipt 16006
TMIGD3 in microglia, braak-0.11 (p 0.787) → -0.01 (p 0.982)receipt 16005

receipt 16006: TMIGD3 in dopamine neurons, braak

power: full sample +0.03 (p 0.894, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.02 (p 0.928, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.774, n 18). could be the mix.
skeptic: leave-one-out range -0.11 to +0.13, sign flips 5; without severely affected donors +0.03 (p 0.894, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMIGD3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 16005: TMIGD3 in microglia, braak

power: full sample -0.11 (p 0.658, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.08 (p 0.761, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.01 (p 0.969, n 18). could be the mix.
skeptic: leave-one-out range -0.23 to +0.03, sign flips 1; without severely affected donors -0.11 (p 0.658, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMIGD3 in microglia.

case closed: nothing better to follow up.

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