Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in proximal tubule cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 11010
Sealed predictions
- TIMM23B in dopamine neurons, braak+0.51 (p 0.165) → +0.19 (p 0.630)receipt 11017
- TIMM23B in microglia, braak-0.21 (p 0.586) → -0.05 (p 0.893)receipt 11016
Swarm cases
receipt 11017: TIMM23B in dopamine neurons, braak
- power
- full sample +0.41 (p 0.087, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.37 (p 0.127, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.37 (p 0.127, n 18). could be the mix.
- skeptic
- leave-one-out range +0.34 to +0.53, sign flips 0; without severely affected donors +0.41 (p 0.087, n 18). robust.
- cell type
- strongest in OPCs: +0.68 (p 0.0018, n 18) vs +0.41 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TIMM23B in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TIMM23B · OPCs · braak: substantia nigra, an independent cohort (already registered)
receipt 11016: TIMM23B in microglia, braak
- power
- full sample -0.36 (p 0.140, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.164, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.32 (p 0.201, n 18). could be the mix.
- skeptic
- leave-one-out range -0.48 to -0.26, sign flips 0; without severely affected donors -0.36 (p 0.140, n 18). fragile.
- cell type
- strongest in OPCs: +0.68 (p 0.0018, n 18) vs -0.36 in microglia. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TIMM23B in microglia.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TIMM23B · OPCs · braak: substantia nigra, an independent cohort: not measured
Receipts
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