Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in pituicytes/fscs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 130 | 0.79 |
| pathways Reactome | 2 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 11807
Sealed predictions
- ST3GAL5 in dopamine neurons, braak-0.01 (p 0.982) → -0.05 (p 0.907)receipt 11814
- ST3GAL5 in oligodendrocytes, braak-0.22 (p 0.576) → +0.30 (p 0.426)receipt 11813
Swarm cases
receipt 11814: ST3GAL5 in dopamine neurons, braak
- power
- full sample -0.08 (p 0.754, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.03 (p 0.908, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.969, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.05, sign flips 2; without severely affected donors -0.08 (p 0.754, n 18). fragile.
- cell type
- strongest in microglia: -0.76 (p 2.7e-4, n 18) vs -0.08 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ST3GAL5 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ST3GAL5 · microglia · braak: substantia nigra, an independent cohort (already registered)
receipt 11813: ST3GAL5 in oligodendrocytes, braak
- power
- full sample +0.05 (p 0.854, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.06 (p 0.807, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.04 (p 0.888, n 18). could be the mix.
- skeptic
- leave-one-out range -0.05 to +0.20, sign flips 4; without severely affected donors +0.05 (p 0.854, n 18). fragile.
- cell type
- strongest in microglia: -0.76 (p 2.7e-4, n 18) vs +0.05 in oligodendrocytes. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ST3GAL5 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ST3GAL5 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.57 p 0.041 (needs p < 1.9e-4)
Receipts
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