parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (28 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 15710

SRCAP in dopamine neurons, braak-0.44 (p 0.232) → +0.23 (p 0.549)receipt 15719
SRCAP in microglia, braak-0.33 (p 0.380) → -0.35 (p 0.350)receipt 15718

receipt 15719: SRCAP in dopamine neurons, braak

power: full sample -0.09 (p 0.709, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.19 (p 0.444, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.18 (p 0.471, n 18). could be the mix.
skeptic: leave-one-out range -0.20 to +0.01, sign flips 1; without severely affected donors -0.09 (p 0.709, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SRCAP in dopamine neurons.

case closed: nothing better to follow up.

receipt 15718: SRCAP in microglia, braak

power: full sample -0.30 (p 0.225, n 18), 95% CI -0.67 to +0.19. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.29 (p 0.250, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.23 (p 0.355, n 18). could be the mix.
skeptic: leave-one-out range -0.49 to -0.21, sign flips 0; without severely affected donors -0.30 (p 0.225, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SRCAP in microglia.

case closed: nothing better to follow up.

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