Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

SPOCK1

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1

translation score 0.44, read 2026-10-28; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in podocytes0.75
chemistry
Open Targets		reachable by antibody0.36
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		1 Parkinson's papers of 1490.91
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 13120

Sealed predictions

  1. SPOCK1 in dopamine neurons, braak-0.06 (p 0.874) → -0.27 (p 0.487)receipt 13128
  2. SPOCK1 in oligodendrocytes, braak+0.00 (p 1.000) → -0.46 (p 0.216)receipt 13127

Swarm cases

receipt 13128: SPOCK1 in dopamine neurons, braak

power
full sample -0.16 (p 0.538, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.17 (p 0.509, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.17 (p 0.504, n 18). could be the mix.
skeptic
leave-one-out range -0.31 to -0.06, sign flips 0; without severely affected donors -0.16 (p 0.538, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SPOCK1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 13127: SPOCK1 in oligodendrocytes, braak

power
full sample -0.19 (p 0.460, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.13 (p 0.609, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.17 (p 0.509, n 18). could be the mix.
skeptic
leave-one-out range -0.34 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.460, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SPOCK1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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