parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in myonuclei	0.75
chemistry Open Targets	hard to drug	0.40
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 14524

receipt 14532: SPEG in dopamine neurons, braak

power: full sample -0.37 (p 0.132, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.39 (p 0.105, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.62 (p 0.0062, n 18). not the mix.
skeptic: leave-one-out range -0.53 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.132, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SPEG in dopamine neurons.

case closed: nothing better to follow up.

receipt 14531: SPEG in astrocytes, braak

power: full sample -0.27 (p 0.277, n 18), 95% CI -0.65 to +0.22. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.26 (p 0.306, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.23 (p 0.369, n 18). could be the mix.
skeptic: leave-one-out range -0.46 to -0.19, sign flips 0; without severely affected donors -0.27 (p 0.277, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SPEG in astrocytes.

case closed: nothing better to follow up.

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