parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in smooth muscle cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 16157

SORBS1 in dopamine neurons, braak-0.25 (p 0.514) → -0.70 (p 0.034)receipt 16165
SORBS1 in astrocytes, braak+0.18 (p 0.646) → -0.26 (p 0.499)receipt 16164

receipt 16165: SORBS1 in dopamine neurons, braak

power: full sample -0.44 (p 0.069, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.48 (p 0.044, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.063, n 18). could be the mix.
skeptic: leave-one-out range -0.61 to -0.36, sign flips 0; without severely affected donors -0.44 (p 0.069, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SORBS1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 16164: SORBS1 in astrocytes, braak

power: full sample -0.02 (p 0.925, n 18), 95% CI -0.49 to +0.45. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.04 (p 0.881, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.03 (p 0.915, n 18). could be the mix.
skeptic: leave-one-out range -0.16 to +0.08, sign flips 6; without severely affected donors -0.02 (p 0.925, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SORBS1 in astrocytes.

case closed: nothing better to follow up.

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