parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (655 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	7 Parkinson's papers of 126	0.73
pathways Reactome	1 pathway; mostly energy	0.60

No case: the score is under the bar. Receipt 9720

receipt 9728: QDPR in dopamine neurons, braak

power: full sample +0.18 (p 0.471, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.19 (p 0.455, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.150, n 18). could be the mix.
skeptic: leave-one-out range +0.07 to +0.31, sign flips 0; without severely affected donors +0.18 (p 0.471, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for QDPR in dopamine neurons.

case closed: nothing better to follow up.

receipt 9727: QDPR in oligodendrocytes, braak

power: full sample +0.08 (p 0.761, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.05 (p 0.847, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.04 (p 0.888, n 18). could be the mix.
skeptic: leave-one-out range -0.06 to +0.23, sign flips 2; without severely affected donors +0.08 (p 0.761, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for QDPR in oligodendrocytes.

case closed: nothing better to follow up.

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