Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 93 | 0.91 |
| pathways Reactome | 3 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 17118
Sealed predictions
- PPM1B in oligodendrocytes, braak+0.54 (p 0.133) → +0.18 (p 0.638)receipt 17125
- PPM1B in dopamine neurons, braak+0.80 (p 0.010) → +0.27 (p 0.487)receipt 17126
Swarm cases
receipt 17126: PPM1B in dopamine neurons, braak
- power
- full sample +0.44 (p 0.069, n 18), 95% CI -0.04 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.43 (p 0.077, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.54 (p 0.021, n 18). not the mix.
- skeptic
- leave-one-out range +0.37 to +0.62, sign flips 0; without severely affected donors +0.44 (p 0.069, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPM1B in dopamine neurons.
case closed: nothing better to follow up.
receipt 17125: PPM1B in oligodendrocytes, braak
- power
- full sample +0.32 (p 0.198, n 18), 95% CI -0.17 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.26 (p 0.289, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.38 (p 0.118, n 18). could be the mix.
- skeptic
- leave-one-out range +0.23 to +0.51, sign flips 0; without severely affected donors +0.32 (p 0.198, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPM1B in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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