parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.17 (overall 0.11)	0.17
cell type Human Protein Atlas	group enriched, including astrocytes; strongest in bergmann glia	0.75
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 2411

receipt 2420: PIRT in dopamine neurons, braak

power: full sample -0.01 (p 0.983, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.00 (p 0.990, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.10 (p 0.683, n 18). could be the mix.
skeptic: leave-one-out range -0.16 to +0.09, sign flips 13; without severely affected donors -0.01 (p 0.983, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PIRT in dopamine neurons.

case closed: nothing better to follow up.

receipt 2419: PIRT in astrocytes, braak

power: full sample -0.25 (p 0.323, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.27 (p 0.285, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.08 (p 0.767, n 18). could be the mix.
skeptic: leave-one-out range -0.37 to -0.14, sign flips 0; without severely affected donors -0.25 (p 0.323, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PIRT in astrocytes.

case closed: nothing better to follow up.

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