parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	group enriched, including oligodendrocytes; strongest in neuroendocrine cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	9 Parkinson's papers of 724	0.70
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 13095

NKX2-2 in dopamine neurons, braak+0.27 (p 0.487) → +0.33 (p 0.385)receipt 13103
NKX2-2 in oligodendrocytes, braak-0.03 (p 0.946) → +0.30 (p 0.428)receipt 13102

receipt 13103: NKX2-2 in dopamine neurons, braak

power: full sample +0.37 (p 0.135, n 18), 95% CI -0.12 to +0.71. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.40 (p 0.099, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.105, n 18). could be the mix.
skeptic: leave-one-out range +0.29 to +0.47, sign flips 0; without severely affected donors +0.37 (p 0.135, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NKX2-2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 13102: NKX2-2 in oligodendrocytes, braak

power: full sample +0.04 (p 0.874, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.06 (p 0.814, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.11 (p 0.652, n 18). could be the mix.
skeptic: leave-one-out range -0.08 to +0.16, sign flips 5; without severely affected donors +0.04 (p 0.874, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NKX2-2 in oligodendrocytes.

case closed: nothing better to follow up.

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