parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	group enriched in astrocytes (54 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 14427

NFATC4 in dopamine neurons, braak-0.12 (p 0.750) → -0.46 (p 0.217)receipt 14435
NFATC4 in astrocytes, braak+0.28 (p 0.472) → +0.21 (p 0.583)receipt 14434

receipt 14435: NFATC4 in dopamine neurons, braak

power: full sample -0.34 (p 0.173, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.38 (p 0.116, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.099, n 18). could be the mix.
skeptic: leave-one-out range -0.47 to -0.25, sign flips 0; without severely affected donors -0.34 (p 0.173, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NFATC4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 14434: NFATC4 in astrocytes, braak

power: full sample +0.22 (p 0.374, n 18), 95% CI -0.27 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.17 (p 0.504, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.16 (p 0.521, n 18). could be the mix.
skeptic: leave-one-out range +0.15 to +0.36, sign flips 0; without severely affected donors +0.22 (p 0.374, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NFATC4 in astrocytes.

case closed: nothing better to follow up.

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