parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in adrenal medulla cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 14440

MYH15 in dopamine neurons, braak+0.75 (p 0.019) → +0.52 (p 0.153)receipt 14448
MYH15 in astrocytes, braak+0.57 (p 0.109) → -0.09 (p 0.825)receipt 14447

receipt 14448: MYH15 in dopamine neurons, braak

power: full sample +0.53 (p 0.025, n 18), 95% CI +0.08 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.50 (p 0.034, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.54 (p 0.021, n 18). not the mix.
skeptic: leave-one-out range +0.45 to +0.69, sign flips 0; without severely affected donors +0.53 (p 0.025, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MYH15 in dopamine neurons.

case closed: nothing better to follow up.

receipt 14447: MYH15 in astrocytes, braak

power: full sample +0.19 (p 0.444, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.24 (p 0.346, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.24 (p 0.346, n 18). could be the mix.
skeptic: leave-one-out range +0.08 to +0.37, sign flips 0; without severely affected donors +0.19 (p 0.444, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MYH15 in astrocytes.

case closed: nothing better to follow up.

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