Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in fibroblasts | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 14888
Sealed predictions
- MATN4 in dopamine neurons, braak-0.57 (p 0.109) → +0.03 (p 0.946)receipt 14897
- MATN4 in oligodendrocytes, braak+0.17 (p 0.656) → -0.67 (p 0.049)receipt 14896
Swarm cases
receipt 14897: MATN4 in dopamine neurons, braak
- power
- full sample -0.41 (p 0.095, n 18), 95% CI -0.73 to +0.08. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.40 (p 0.099, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.046, n 18). not the mix.
- skeptic
- leave-one-out range -0.57 to -0.33, sign flips 0; without severely affected donors -0.41 (p 0.095, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MATN4 in dopamine neurons.
case closed: nothing better to follow up.
receipt 14896: MATN4 in oligodendrocytes, braak
- power
- full sample -0.24 (p 0.328, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.28 (p 0.265, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.42 (p 0.080, n 18). could be the mix.
- skeptic
- leave-one-out range -0.39 to -0.15, sign flips 0; without severely affected donors -0.24 (p 0.328, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MATN4 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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