parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in oocytes	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 12495

MAP4K1 in dopamine neurons, braak-0.38 (p 0.309) → -0.58 (p 0.104)receipt 12505
MAP4K1 in microglia, braak-0.26 (p 0.502) → -0.07 (p 0.859)receipt 12504

receipt 12505: MAP4K1 in dopamine neurons, braak

power: full sample -0.39 (p 0.105, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.43 (p 0.075, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.029, n 18). not the mix.
skeptic: leave-one-out range -0.54 to -0.32, sign flips 0; without severely affected donors -0.39 (p 0.105, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MAP4K1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12504: MAP4K1 in microglia, braak

power: full sample -0.14 (p 0.591, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.13 (p 0.609, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.10 (p 0.683, n 18). could be the mix.
skeptic: leave-one-out range -0.30 to -0.01, sign flips 0; without severely affected donors -0.14 (p 0.591, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MAP4K1 in microglia.

case closed: nothing better to follow up.

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