Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in alveolar cells type 1 | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 104 | 0.76 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 13357
Sealed predictions
- LMO3 in astrocytes, braak+0.28 (p 0.459) → -0.33 (p 0.388)receipt 13365
- LMO3 in dopamine neurons, braak-0.04 (p 0.924) → +0.55 (p 0.122)receipt 13366
Swarm cases
receipt 13366: LMO3 in dopamine neurons, braak
- power
- full sample +0.14 (p 0.579, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.13 (p 0.621, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.01 (p 0.962, n 18). could be the mix.
- skeptic
- leave-one-out range +0.04 to +0.28, sign flips 0; without severely affected donors +0.14 (p 0.579, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LMO3 in dopamine neurons.
case closed: nothing better to follow up.
receipt 13365: LMO3 in astrocytes, braak
- power
- full sample +0.03 (p 0.894, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.03 (p 0.894, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.03 (p 0.894, n 18). could be the mix.
- skeptic
- leave-one-out range -0.10 to +0.15, sign flips 5; without severely affected donors +0.03 (p 0.894, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LMO3 in astrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts