parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in müller glia	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 403	0.91
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 13154

receipt 13162: LHX2 in dopamine neurons, braak

power: full sample -0.41 (p 0.087, n 18), 95% CI -0.74 to +0.07. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.41 (p 0.087, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.014, n 18). not the mix.
skeptic: leave-one-out range -0.59 to -0.34, sign flips 0; without severely affected donors -0.41 (p 0.087, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LHX2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 13161: LHX2 in astrocytes, braak

power: full sample +0.28 (p 0.269, n 18), 95% CI -0.22 to +0.66. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.34 (p 0.164, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.26 (p 0.298, n 18). could be the mix.
skeptic: leave-one-out range +0.18 to +0.43, sign flips 0; without severely affected donors +0.28 (p 0.269, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LHX2 in astrocytes.

case closed: nothing better to follow up.

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