Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in proximal tubule cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 165 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 15514
Sealed predictions
- KLF13 in dopamine neurons, braak-0.12 (p 0.767) → -0.63 (p 0.068)receipt 15522
- KLF13 in oligodendrocytes, braak-0.84 (p 0.005) → -0.63 (p 0.069)receipt 15521
Swarm cases
receipt 15522: KLF13 in dopamine neurons, braak
- power
- full sample -0.43 (p 0.077, n 18), 95% CI -0.75 to +0.05. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.52 (p 0.027, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.63 (p 0.0053, n 18). not the mix.
- skeptic
- leave-one-out range -0.51 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.077, n 18). robust.
- cell type
- strongest in oligodendrocytes: -0.73 (p 5.3e-4, n 18) vs -0.43 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KLF13 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up KLF13 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.63 p 0.026 (needs p < 1.5e-4)
receipt 15521: KLF13 in oligodendrocytes, braak
- power
- full sample -0.73 (p 5.3e-4, n 18), 95% CI -0.89 to -0.41. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.70 (p 0.0011, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.76 (p 2.7e-4, n 18). not the mix.
- skeptic
- leave-one-out range -0.79 to -0.70, sign flips 0; without severely affected donors -0.73 (p 5.3e-4, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KLF13 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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