parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in pericytes	0.75
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 17264

KCNE4 in dopamine neurons, braak+0.32 (p 0.400) → +0.44 (p 0.234)receipt 17272
KCNE4 in astrocytes, braak+0.21 (p 0.579) → -0.28 (p 0.459)receipt 17271

receipt 17272: KCNE4 in dopamine neurons, braak

power: full sample +0.36 (p 0.145, n 18), 95% CI -0.13 to +0.71. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.35 (p 0.150, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.41 (p 0.093, n 18). could be the mix.
skeptic: leave-one-out range +0.26 to +0.50, sign flips 0; without severely affected donors +0.36 (p 0.145, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for KCNE4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 17271: KCNE4 in astrocytes, braak

power: full sample +0.05 (p 0.840, n 18), 95% CI -0.43 to +0.51. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.10 (p 0.683, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
skeptic: leave-one-out range -0.04 to +0.16, sign flips 4; without severely affected donors +0.05 (p 0.840, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for KCNE4 in astrocytes.

case closed: nothing better to follow up.

loading the receipts