parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (144 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 317	0.85
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 15230

IFI44L in microglia, braak+0.03 (p 0.947) → +0.15 (p 0.705)receipt 15237
IFI44L in dopamine neurons, braak+0.44 (p 0.232) → +0.09 (p 0.815)receipt 15238

receipt 15238: IFI44L in dopamine neurons, braak

power: full sample +0.25 (p 0.323, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.28 (p 0.269, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.27 (p 0.277, n 18). could be the mix.
skeptic: leave-one-out range +0.16 to +0.37, sign flips 0; without severely affected donors +0.25 (p 0.323, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IFI44L in dopamine neurons.

case closed: nothing better to follow up.

receipt 15237: IFI44L in microglia, braak

power: full sample -0.01 (p 0.983, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.983, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.00 (p 0.997, n 18). could be the mix.
skeptic: leave-one-out range -0.08 to +0.15, sign flips 4; without severely affected donors -0.01 (p 0.983, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IFI44L in microglia.

case closed: nothing better to follow up.

loading the receipts