parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in fallopian secretory cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 551	0.91
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 14316

receipt 14326: ID4 in dopamine neurons, braak

power: full sample +0.23 (p 0.365, n 18), 95% CI -0.27 to +0.63. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.23 (p 0.365, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.365, n 18). could be the mix.
skeptic: leave-one-out range +0.14 to +0.41, sign flips 0; without severely affected donors +0.23 (p 0.365, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ID4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 14325: ID4 in astrocytes, braak

power: full sample -0.09 (p 0.722, n 18), 95% CI -0.53 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.10 (p 0.702, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.02 (p 0.949, n 18). could be the mix.
skeptic: leave-one-out range -0.22 to +0.02, sign flips 3; without severely affected donors -0.09 (p 0.722, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ID4 in astrocytes.

case closed: nothing better to follow up.

loading the receipts