Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in renal collecting duct intercalated cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 15979
Sealed predictions
- GTF2H2C in dopamine neurons, braak+0.12 (p 0.767) → -0.03 (p 0.947)receipt 15988
- GTF2H2C in oligodendrocytes, braak+0.26 (p 0.500) → -0.49 (p 0.184)receipt 15987
Swarm cases
receipt 15988: GTF2H2C in dopamine neurons, braak
- power
- full sample +0.07 (p 0.794, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.748, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.573, n 18). could be the mix.
- skeptic
- leave-one-out range -0.05 to +0.17, sign flips 4; without severely affected donors +0.07 (p 0.794, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GTF2H2C in dopamine neurons.
case closed: nothing better to follow up.
receipt 15987: GTF2H2C in oligodendrocytes, braak
- power
- full sample -0.08 (p 0.741, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.609, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.09 (p 0.735, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.02, sign flips 1; without severely affected donors -0.08 (p 0.741, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GTF2H2C in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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