parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	group enriched, including microglia; strongest in hofbauer cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 110	0.85
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 15288

GPR34 in dopamine neurons, braak+0.21 (p 0.586) → +0.42 (p 0.258)receipt 15296
GPR34 in microglia, braak-0.42 (p 0.258) → +0.56 (p 0.118)receipt 15295

receipt 15296: GPR34 in dopamine neurons, braak

power: full sample +0.32 (p 0.201, n 18), 95% CI -0.18 to +0.68. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.44 (p 0.069, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.170, n 18). could be the mix.
skeptic: leave-one-out range +0.22 to +0.43, sign flips 0; without severely affected donors +0.32 (p 0.201, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GPR34 in dopamine neurons.

case closed: nothing better to follow up.

receipt 15295: GPR34 in microglia, braak

power: full sample +0.11 (p 0.652, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.14 (p 0.579, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.36 (p 0.142, n 18). could be the mix.
skeptic: leave-one-out range +0.00 to +0.24, sign flips 0; without severely affected donors +0.11 (p 0.652, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GPR34 in microglia.

case closed: nothing better to follow up.

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