Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocyte progenitor cells (190 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 12055
Sealed predictions
- GOLGA8A in dopamine neurons, braak+0.29 (p 0.445) → -0.05 (p 0.891)receipt 12064
- GOLGA8A in oligodendrocytes, braak+0.40 (p 0.292) → +0.69 (p 0.042)receipt 12063
Swarm cases
receipt 12064: GOLGA8A in dopamine neurons, braak
- power
- full sample +0.18 (p 0.471, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.14 (p 0.567, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.585, n 18). could be the mix.
- skeptic
- leave-one-out range +0.08 to +0.32, sign flips 0; without severely affected donors +0.18 (p 0.471, n 18). fragile.
- cell type
- strongest in oligodendrocytes: +0.61 (p 0.0069, n 18) vs +0.18 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GOLGA8A in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up GOLGA8A · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.25 p 0.374 (needs p < 1.8e-4)
receipt 12063: GOLGA8A in oligodendrocytes, braak
- power
- full sample +0.61 (p 0.0069, n 18), 95% CI +0.20 to +0.84. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.59 (p 0.0099, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.55 (p 0.018, n 18). not the mix.
- skeptic
- leave-one-out range +0.57 to +0.85, sign flips 0; without severely affected donors +0.61 (p 0.0069, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GOLGA8A in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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