Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in papillary tip epithelial cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 177 | 0.85 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 13325
Sealed predictions
- DTX2 in dopamine neurons, braak-0.49 (p 0.177) → -0.28 (p 0.472)receipt 13333
- DTX2 in microglia, braak-0.24 (p 0.539) → +0.05 (p 0.893)receipt 13332
Swarm cases
receipt 13333: DTX2 in dopamine neurons, braak
- power
- full sample -0.40 (p 0.103, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.41 (p 0.093, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.055, n 18). could be the mix.
- skeptic
- leave-one-out range -0.53 to -0.31, sign flips 0; without severely affected donors -0.40 (p 0.103, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.66 (p 0.0031, n 18) vs -0.40 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DTX2 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up DTX2 · oligodendrocytes · braak: substantia nigra, an independent cohort (already registered)
receipt 13332: DTX2 in microglia, braak
- power
- full sample -0.06 (p 0.800, n 18), 95% CI -0.52 to +0.42. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.621, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.08 (p 0.754, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.08, sign flips 3; without severely affected donors -0.06 (p 0.800, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.66 (p 0.0031, n 18) vs -0.06 in microglia. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DTX2 in microglia.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up DTX2 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.32 p 0.248 (needs p < 1.7e-4)
Receipts
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