Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in neutrophils | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 86 | 0.85 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 13389
Sealed predictions
- DOCK5 in dopamine neurons, braak+0.05 (p 0.894) → +0.20 (p 0.613)receipt 13396
- DOCK5 in oligodendrocytes, braak+0.74 (p 0.023) → +0.28 (p 0.464)receipt 13395
Swarm cases
receipt 13396: DOCK5 in dopamine neurons, braak
- power
- full sample +0.12 (p 0.627, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.658, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.709, n 18). could be the mix.
- skeptic
- leave-one-out range +0.00 to +0.23, sign flips 0; without severely affected donors +0.12 (p 0.627, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DOCK5 in dopamine neurons.
case closed: nothing better to follow up.
receipt 13395: DOCK5 in oligodendrocytes, braak
- power
- full sample +0.15 (p 0.549, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.15 (p 0.549, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.24 (p 0.337, n 18). could be the mix.
- skeptic
- leave-one-out range +0.04 to +0.22, sign flips 0; without severely affected donors +0.15 (p 0.549, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DOCK5 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts